Tailoring of microbes for the production of high value plant-derived compounds: From pathway engineering to fermentative production

Plant natural products have been an attracting platform for the isolation of various active drugs and other bioactives. However large-scale extraction of these compounds is affected by the difficulty in mass cultivation of these plants and absence of strategies for successful extraction. Even though, synthesis by chemical method is an alternative method; it is less efficient as their chemical structure is highly complex which involve enantio-selectivity. Thus an alternate bio-system for heterologous production of plant natural products using microbes has emerged. Advent of various omics, synthetic and metabolic engineering strategies revolutionised the field of heterologous plant metabolite production. In this context, various engineering methods taken to synthesise plant natural products are described with an additional focus to fermentation strategies. Schematic representation of design of microbial cell factory for production of high value plant-derived compounds. [Display omitted] •Development of engineered hosts for bioactive plant compounds•Identification and engineering of plant biosynthetic pathways in microbes•Impact of synthetic biology in recombinant plant bioactive production•Fermentation and its impact in natural compound production