Novel aspects of muscle involvement in immune-mediated inflammatory arthropathies and connective tissue diseases

Myalgia, myopathy and myositis are the most important types of muscle impairment in immune-mediated inflammatory arthropathies and connective tissue diseases. Multiple pathogenetic and histological changes occur in the striated muscles of these patients. Clinically, the most important muscle involvement is the one that causes complaints to the patients. In everyday practice, insidious symptoms present a serious problem for the clinician; in many cases, it is difficult to decide when and how to treat the muscle symptoms that are often present only subclinically. In this work, authors review the international literature on the types of muscle problems in autoimmune diseases. In scleroderma histopathological picture of muscle shows a very heterogeneous picture, necrosis and atrophy are common. In rheumatoid arthritis and systemic lupus erythematosus, myopathy is a much less defined concept, further studies are needed to describe it. According to our view, overlap myositis should be recognized as a separate entity, preferably with distinct histological and serological characteristics. More studies are needed to describe muscle impairment in autoimmune diseases which may help to explore this topic more in depth and be of clinical use. •In autoimmune diseases one of the most important representatives of tissue specific manifestations is muscle involvement.•There are two possible causes of muscle symptoms in rheumatoid arthritis: the disease itself and drug effects•In ankylosing spondylitis, inflammation, enthesopathies, bone lesions are responsible for muscle symptoms.•Scleroderma myopathy represents a heterogeneous group of muscle diseases.•It is important to decide whether it is a basic symptom or due to sedentary lifestyle or corticosteroids.