Quantitative detection of cervical cancer based on time series information from smear images

Existing cervical cancer detection methods usually screen the samples based on separated cells. Cell misclassification leads to poor robustness and accuracy, quantitative analysis is missed. Global smear information and cell relationship are also not fully utilized. Aiming at the mentioned limitations, a cervical quantitative detection framework which combines the fine-tuned Long Short-Term Memory Fully Convolutional Network and Fuzzy Nonlinear Regression is proposed. Time series-based​ screening improves the detection performance. Deoxyribonucleic Acid (DNA) value is better expressed by the rectified method using soft computing. A cervical dataset containing 657 samples is used for training and validation, accuracy, sensitivity, and specificity of 98.3%, 98.1% and 97.9% are achieved with the time series features, providing an automatic and effective way for the computer-assisted screening of cervical cancer. •Time series-based detection frame is applied for cervical cancer.•Segmentation & detection is applied to generate cells for quantitative analysis.•Fuzzy analysis for calculation and rectifying of cell ploidy is proposed.•Diagnoses of cervical cancer is made on the prediction of fine-tuned LSTM-FCN model.•Concept of time series for cervical cancer classification is proposed and expatiated.