Evaluation on the effects of phage cocktail in preventing Aeromonas veronii infection in Gibel carps (Carassius auratus gibelio)

Members in Aeromonas genus especially for Aeromonas veronii isolates are ubiquitous in aquaculture environments and have increasingly implicated in diseases of fish, and many of them have multidrug resistance. In this work, we used a phage cocktail as an alternative strategy to combat the infection of A. veronii 1810 in gibel carps. Three bacteriophages were isolated and designated as pAEv1810, pAEv1812 and pAEv1818. Electron microscopy observation revealed that all three phages belonged to the order of Caudovirales. Host spectrum assay showed that all three phages were lytic to A. veronii 1810 and pAEv1812 had a relatively broad host range. The cocktail combined with the three phages performed a significant inhibition (P