Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning

[Display omitted] •The wound healing bilayer film was developed using air-jet spinning.•(+)-catechin has antioxidant activity and was confirmed by NO assay.•Our results suggest that PCL/(+)-catechin/gelatin film has excellent antioxidant activity and potentially good wound healing agents. Air-jet spinning has been used to fabricate fibers with nano-micro diameters and is widely applied in medical products such as wound treatment patches, gauze, and graft scaffolds. In particular, wounds vary from light to deep, and basically the wound is vulnerable to infection by external harmful factors. Therefore, blocking harmful factors from entering the wound area is very important. In addition, the wound site has high levels of oxidative stress, and thus the use of antioxidants is suggested as a good solution for wound treatment. We developed wound healing agents using gelatin, which shows excellent biocompatibility, catechin, which has high antioxidant activity, and polycaprolactone, which was spun on catechin and gelatin films, to produce a double layered structure using air-jet spinning. This structure blocked harmful external factors and is a candidate for efficient wound treatment.