Long-term nitric oxide release for rapid endothelialization in expanded polytetrafluoroethylene small-diameter artificial blood vessel grafts

[Display omitted] •Functional biomolecules, such as selenocystamine (SeCA) and vascular endothelial growth factor (VEGF), were successfully grafted onto the surface of ePTFE via dopamine coating.•The release profile of NO lasted beyond 35 days and could be controlled by the ratio of SeCA to dopamine, preventing platelet adhesion and the formation of thrombi in vitro.•A complete endothelial cell monolayer on ePTFE was found to form by day 10. Without a complete and confluent endothelial layer covering the luminal surface, expanded polytetrafluoroethylene (ePTFE) small-diameter (