Risk factors for early-phase clozapine discontinuation: A nested case-control study

Risk factors for early-phase clozapine discontinuation: A nested case-control study

•Clozapine treatment was discontinued in 15 (6.6 %) patients within 12 weeks.•Eosinophilia was a frequent reason for clozapine discontinuation in this cohort.•Clozapine-induced eosinophilia was associated with concomitant valproate use.•A history of smoking was a risk for clozapine discontinuation.•...

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Veröffentlicht in:Asian journal of psychiatry 2021-08, Vol.62, p.102745-102745, Article 102745
Hauptverfasser: Tsukiji, Mariko, Sasaki, Tsuyoshi, Nakata, Yusuke, Ota, Kiyomitsu, Aoki, Tsutomu, Hara, Koichiro, Mamada, Takashi, Nakane, Jun, Kogure, Masanobu, Seki, Ryota, Idemoto, Keita, Hashimoto, Tasuku, Koishikawa, Hiraki, Moriyama, Toshihiro, Suzuki, Takaaki, Kanahara, Nobuhisa, Ishii, Itsuko, Iyo, Masaomi, Niitsu, Tomihisa
Format: Artikel
Sprache:eng
Schlagworte:
Antipsychotic
Clozapine
Eosinophilia
Life Sciences & Biomedicine
Psychiatry
Science & Technology
Switching strategy
Treatment-resistant schizophrenia
Valproate
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Zusammenfassung:•Clozapine treatment was discontinued in 15 (6.6 %) patients within 12 weeks.•Eosinophilia was a frequent reason for clozapine discontinuation in this cohort.•Clozapine-induced eosinophilia was associated with concomitant valproate use.•A history of smoking was a risk for clozapine discontinuation.•Prior antipsychotic (CPZ-eq dose
ISSN:1876-2018
1876-2026
DOI:10.1016/j.ajp.2021.102745