Towards effective antimicrobial agents: tailoring metal complexes derived acetyl acetone-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and 2-aminothiazole schiff base

The present research showcases the synthesis of novel metal complexes including Cu (II), Ni (II), Co (II), VO (II), and Zn (II) derived from Acetyl Acetone-4-Imino-2, 3-Dimethyl-1-Phenyl-3-Pyrazolin-5-One and 2-Aminothiazole. Various analytical techniques such as Powder X-ray diffraction (PXRD), Scanning electron microscopy (SEM) for morphological studies, UV–Vis spectroscopy, FT-IR, 1 H-NMR spectroscopy, elemental analysis, Electron spin resonance (ESR), and magnetic susceptibility measurements were employed to thoroughly characterize these complexes. The analysis of FT-IR, magnetic susceptibility, and UV–Vis spectra of the complexes suggests a square planar geometry for most, except for the metal complex [VOL]Cl, which exhibits a rectangular pyramidal geometry. Cyclic voltammetry analysis of [VOL]Cl and [CuL]Cl complexes in MeCN reveals that the coordinated ligands play a role in influencing the redox potential of the metal ions. Powder XRD data and SEM images indicate that the composite materials consist of small-sized grains with a polycrystalline structure. This study also explores the antimicrobial properties of novel schiff base metal complexes using biologically active ligands. The complexes exhibit enhanced antimicrobial activity compared to free ligands, as demonstrated by minimum inhibitory concentration (MIC) values against various bacterial and fungal strains. These findings highlight the potential of metal coordination in drug design and set the stage for future investigations into their therapeutic applications. Highlights Innovative Complex Synthesis: Successfully synthesized and characterized five novel metal complexes (Cu(II), Ni(II), Co(II), VO(II), Zn(II)) derived from a unique schiff base ligand, demonstrating innovative coordination chemistry. Diverse Structural Geometries: Unveiled distinct structural geometries, with most complexes exhibiting square planar coordination, while [VOL]Cl uniquely adopts a rectangular pyramidal structure, highlighting the influence of the metal center on geometry. Comprehensive Analytical Profiling: Employed a multifaceted approach using FT-IR, UV–Vis, NMR, ESR, PXRD, SEM, and cyclic voltammetry, providing an in-depth understanding of the complexes structural, electronic, and morphological properties. Enhanced Antimicrobial Efficacy: Demonstrated superior antimicrobial activity of metal complexes over the free ligand, underscoring their potential as advanced antimicrobial agents with significant practica