The Performance of a Body Composition–Based Equation in Estimating Overhydration of Hemodialysis Patients

Achieving and maintaining optimal fluid status remains a major challenge in maintenance hemodialysis (MHD). The aim of this study was to establish a body composition–based multiple regression equation for use in the estimation of overhydration (OH) in the setting of MHD while using a body composition monitor (BCM) to guide patient dry weight management. We initially retrospectively analyzed factors associated with OH in 314 healthy Chinese individuals and obtained a multiple linear regression equation to determine OH level. Next, 49 stable MHD patients were enrolled to validate whether our multiple regression formula was applicable to such patients. Prior to hemodialysis, BCM measurements were performed; OH pre was defined as OH directly measured by BCM; while OH std was defined as OH estimated by the multiple regression equation. In our multivariate linear regression analysis, PhA (β = − 1.266, 95% CI (− 1.532 ~ − 1.341), p