Multi-step continuous flow synthesis of fluconazole

Multi-step continuous flow synthesis of fluconazole

The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapo...

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Veröffentlicht in:Journal of flow chemistry 2019-03, Vol.9 (1), p.35-42
Hauptverfasser: Szeto, Judy, Vu, Vi-Anh, Malerich, Jeremiah P., Collins, Nathan
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Green Chemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Nanochemistry
Organic Chemistry
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Zusammenfassung:The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system. Graphical abstract ᅟ
ISSN:2062-249X
2063-0212
DOI:10.1007/s41981-018-0019-0