A Review of the Use of Pyriproxyfen for Controlling Aedes aegypti in Argentina

Purpose of Review Aedes aegypti (L.) is the main vector of dengue, yellow fever, Zika, and chikungunya viruses in many parts of the world affecting millions of people worldwide each year. Its control is mostly aimed at the larval stages (removal of breeding sites, larviciding, and community education) to reduce the population of new adults. This review is a compilation of recent studies carried out in Argentina with the insect growth regulator (IGR) pyriproxyfen applied for controlling different life stages of the mosquito Aedes aegypti . Recent Findings Pyriproxyfen (PPF) is an increasingly used hormone analog that prevents juvenile Aedes mosquitoes from becoming adults and being incapable of transmitting dengue. It exhibits a high level of activity against mosquito larvae inhibiting adult emergence at very low doses. Additionally, effects on adult mosquito fecundity and fertility after IGR treatments were identified. Summary IGRs have been reported to be selective against target species, with considerable safety to the environment and nontarget organisms, including mammals. Its high efficacy as a larvicide at very low doses, together with its proven effects on adult reproduction, makes it an excellent candidate for use within an integrated vector management program.