LncRNAs and the Control of Oncogenic Signaling

An increasing amount of evidence points to key roles for noncoding RNAs in gene expression regulation and cell function. Similar to smaller species, long noncoding RNAs (lncRNAs) are involved in a myriad of molecular pathways, impacting on and fine-tuning proliferative and differentiating cellular programs. Specifically in tumorigenesis, several lncRNAs have been shown to display growth enhancing or arrest properties and can therefore be considered as true oncogenes or tumor suppressor genes. This review focuses on the latest findings in the noncoding field regarding transcripts with crucial roles in proliferative signaling.