Involvement of glutamate receptors of the paragigantocellularis lateralis nucleus in the pain modulatory effect of 17β-estradiol in male rats

The pain modulatory role of the paragigantocellularis lateralis nucleus (LPGi) and the 17β-estradiol has thoroughly been probed. This study investigates the contribution of ionotropic glutamate receptors in pain modulatory effect of intra-LPGi injection of 17β-estradiol. For this purpose, the LPGi n...

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Veröffentlicht in:	Acta neurologica Belgica 2020-06, Vol.120 (3), p.653-660
Hauptverfasser:	Khakpay, Roghaieh, Azaddar, Maryam, Khakpai, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Estradiol - metabolism Estradiol - pharmacology Formaldehyde - toxicity Irritants - toxicity Male Medicine/Public Health Medulla Oblongata - drug effects Medulla Oblongata - metabolism Neurology Neuroradiology Neurosciences Original Article Pain - chemically induced Pain - metabolism Pain Measurement Rats Rats, Wistar Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism
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Zusammenfassung:	The pain modulatory role of the paragigantocellularis lateralis nucleus (LPGi) and the 17β-estradiol has thoroughly been probed. This study investigates the contribution of ionotropic glutamate receptors in pain modulatory effect of intra-LPGi injection of 17β-estradiol. For this purpose, the LPGi nucleus cannulation was performed and drugs were injected into this nucleus, 15 min prior to the formalin test. The duration of formalin-induced flexing and licking behaviors was recorded for 60 min immediately after formalin injection. The results showed that the flexing behavior is significantly decreased by intra-LPGi injection of 0.8 µmol 17β-estradiol duringboth phases of formalin test ( P
ISSN:	0300-9009 2240-2993
DOI:	10.1007/s13760-018-0998-5