New one-pot approach to regio-synthesis of substituted 2-aminothiazoles from the corresponding keto-aziridines

New one-pot approach to regio-synthesis of substituted 2-aminothiazoles from the corresponding keto-aziridines

Ring expansion of keto-aziridines to the corresponding 2-aminothiazoles (54–67 %) using ammonium thiocyanate in the presence of RuCl 3 under refluxing acetonitrile is described. A plausible mechanism for the synthesis of substituted 2-aminothiazoles has been proposed.

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Veröffentlicht in:Journal of the Iranian Chemical Society 2014-02, Vol.11 (1), p.69-73
Hauptverfasser: Samimi, Heshmat A., Mohammadi, Somaye
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Zusammenfassung:Ring expansion of keto-aziridines to the corresponding 2-aminothiazoles (54–67 %) using ammonium thiocyanate in the presence of RuCl 3 under refluxing acetonitrile is described. A plausible mechanism for the synthesis of substituted 2-aminothiazoles has been proposed.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-013-0276-7