An efficient synthesis of furo[3,4-c]coumarins via the reaction of salicylaldehydes, β-ketoesters and isocyanides

An efficient synthesis of furo[3,4-c]coumarins via the reaction of salicylaldehydes, β-ketoesters and isocyanides

A new, practical and efficient method for the synthesis of furo[3,4- c ]coumarins via the one-pot reaction of salicylaldehydes, β-ketoesters and isocyanides in the presence of piperidine in toluene has been reported. Reaction of 2-hydroxynaphthalene-1-carboxaldehyde, ethyl acetoacetate and cyclohexy...

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Veröffentlicht in:Journal of the Iranian Chemical Society 2013-10, Vol.10 (5), p.851-856
Hauptverfasser: Imanieh, Hossein, Sarlak, Mansooreh, Amanpour, Tayebeh, Bazgir, Ayoob
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Zusammenfassung:A new, practical and efficient method for the synthesis of furo[3,4- c ]coumarins via the one-pot reaction of salicylaldehydes, β-ketoesters and isocyanides in the presence of piperidine in toluene has been reported. Reaction of 2-hydroxynaphthalene-1-carboxaldehyde, ethyl acetoacetate and cyclohexyl isocyanide resulted in the formation of benzo[ f ]furo[3,4- c ]coumarin. Graphical Abstract
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-013-0220-x