Evaluation and Treatment of Stem Cell Transplant-Related Dermatoses

Skin eruptions that develop early after hematopoietic stem cell transplantation are a unique group of dermatoses that are often clinically and histologically similar to one another, despite the variability in etiology. Current diagnostic criteria cannot reliably distinguish between acute graft-versus-host disease, eruption of lymphocyte recovery, engraftment syndrome, toxic erythema of chemotherapy, drug eruptions, and viral exanthema. Prospective trials that incorporate biomarker panels and participation by dermatology consultants in the evaluation of these patients hold promise as a method by which more accurate diagnosis of these dermatoses can be made.