Testicular, sperm and haematological toxicity of ridomil and chlorpyriphos in single and combined exposure

This study was carried out to investigate the effect of Ridomil and Chlorpyriphos, singly and in combination, on testes histology, sperm parameters, and haematological indices in male albino rat model. In a completely randomized design, thirty five experimental subjects were constituted into seven equal treatment groups: A (control); CH1 (25 mg of Chlorpyriphos/kg bw); CH2 (50 mg of Chlorpyriphos/kg bw); R1 (25 mg of Ridomil/kg bw); R2 (50 mg of Ridomil/kg bw); COM1 (12.5 mg of Chlorpyriphos/kg bw+12.5 mg of Ridomil/kg bw); and COM2 (25 mg of Chlorpyriphos/kg bw+25 mg of Ridomil/kg bw); which orally received the stated pesticide treatments, thrice a week, at forty eight hour intervals for eight weeks; after which the animals were sacrificed and tissues obtained. Analysis of variance revealed significantly (P