Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration

Bioinspired 3D scaffolds with antimicrobial, drug delivery, and osteogenic functions for bone regeneration

A major clinical challenge today is the large number of bone defects caused by diseases or trauma. The development of three-dimensional (3D) scaffolds with adequate properties is crucial for successful bone repair. In this study, we prepared biomimetic mesoporous bioactive glass (MBG)-based scaffold...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Drug delivery and translational research 2024-04, Vol.14 (4), p.1028-1047
Hauptverfasser: Atkinson, Irina, Seciu-Grama, Ana-Maria, Serafim, Andrada, Petrescu, Simona, Voicescu, Mariana, Anghel, Elena Maria, Marinescu, Cornelia, Mitran, Raul Augustin, Mocioiu, Oana Catalina, Cusu, Jeanina Pandele, Lincu, Daniel, Prelipcean, Ana-Maria, Craciunescu, Oana
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Original Article
Pharmaceutical Sciences/Technology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A major clinical challenge today is the large number of bone defects caused by diseases or trauma. The development of three-dimensional (3D) scaffolds with adequate properties is crucial for successful bone repair. In this study, we prepared biomimetic mesoporous bioactive glass (MBG)-based scaffolds with and without ceria addition (up to 3 mol %) to explore the biological structure and chemical composition of the marine sponge Spongia Agaricina (SA) as a sacrificial template. Micro-CT examination revealed that all scaffolds exhibited a highly porous structure with pore diameters primarily ranging from 143.5 μm to 213.5 μm, facilitating bone ingrowth. Additionally, smaller pores (
ISSN:2190-393X
2190-3948
DOI:10.1007/s13346-023-01448-y