Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma

The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer mod...

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Veröffentlicht in:	Drug delivery and translational research 2017-08, Vol.7 (4), p.571-581
Hauptverfasser:	Soleimani, Amir H., Garg, Shyam M., Paiva, Igor M., Vakili, Mohammad R., Alshareef, Abdulraheem, Huang, Yung-Hsing, Molavi, Ommoleila, Lai, Raymond, Lavasanifar, Afsaneh
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminosalicylic Acids - administration & dosage Aminosalicylic Acids - chemistry Aminosalicylic Acids - pharmacology Aminosalicylic Acids - therapeutic use Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzenesulfonates - administration & dosage Benzenesulfonates - chemistry Benzenesulfonates - pharmacology Benzenesulfonates - therapeutic use Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cell Survival - drug effects Dendritic Cells - drug effects Dendritic Cells - immunology Dimerization Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacology Drug Carriers - therapeutic use Drug Liberation Female Lactones - administration & dosage Lactones - chemistry Lactones - pharmacology Lactones - therapeutic use Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Mice, Inbred C57BL Micelles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - therapeutic use Original Article Pharmaceutical Sciences/Technology Polyesters - administration & dosage Polyesters - chemistry Polyesters - pharmacology Polyesters - therapeutic use Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polyethylene Glycols - therapeutic use Solubility STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - secretion
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Zusammenfassung:	The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer model, in vitro and in vivo. STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)- b -poly(ε-caprolactone) (PEO 114 - b -PCL 22 ) and methoxy poly(ethylene oxide)- b -poly(α-benzyl carboxylate-ε-caprolactone) (PEO 114 - b -PBCL 20 ) micelles using co-solvent evaporation. Polymeric micelles of S3I-1757 showed high encapsulation efficiency (>88%), slow release profile (
ISSN:	2190-393X 2190-3948
DOI:	10.1007/s13346-017-0369-4