Hypertonic (3%) saline Vs 0.9% saline nebulization for acute viral bronchiolitis: A randomized controlled trial

Objective To compare the length of hospital stay (primary) and improvement in clinical severity scores (secondary) among children with bronchiolitis nebulized with 3 % hypertonic saline or 0.9% saline. Design Randomized double blind controlled trial. Setting Tertiary care teaching hospital. Patients Hospitalized children (1–24 months) with acute bronchiolitis of moderate severity. Intervention Nebulization of 4 ml of 3% hypertonic saline or 4 mL of 0.9% saline, along with 2.5 mg salbutamol, at 4-hourly intervals till the patient was ready for discharge. Results Baseline characteristics were similar in two groups. Median clinical severity score at admission was 6 (IQR-1) in both the groups. Clinical severity scores monitored afterwards 12-hourly till discharge (132 h) did not show statistically significant differences in 3% and 0.9% saline groups. Mean length of hospital stay (time to reach predefined clinical severity score