Ki-67, TGF-β1, and elastin content are significantly altered in lip carcinogenesis

Epithelial changes observed in actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC) have been studied using different markers in order to observe diagnostic and prognostic factors for both lesions. The aim of the present study was to analyze Ki-67, TGF-β1, and elastin content in AC a...

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Veröffentlicht in:Tumor biology 2014-08, Vol.35 (8), p.7635-7644
Hauptverfasser: Salvadori, Gabriela, dos Santos, Jean Nunes, Martins, Marco Antonio Trevizani, Vasconcelos, Artur Cunha, Meurer, Luise, Rados, Pantelis Varvaki, Carrard, Vinicius Coelho, Martins, Manoela Domingues
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Sprache:eng
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Zusammenfassung:Epithelial changes observed in actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC) have been studied using different markers in order to observe diagnostic and prognostic factors for both lesions. The aim of the present study was to analyze Ki-67, TGF-β1, and elastin content in AC and LLSCC to determine the possible role of these proteins in lip carcinogenesis. Medical records of 29 cases of AC and 53 cases of LLSCC were analyzed. Lesions were classified according histological pattern and submitted to immunostaining for Ki-67, TGF-β1, and elastin. Different percentages of Ki-67-positive cells were found in AC depending on the degree of epithelial dysplasia ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-1989-7