Determination of Bisphenol A in Food and Environmental Samples Using Combined Solid-Phase Extraction–Dispersive Liquid–Liquid Microextraction with Solidification of Floating Organic Drop Followed by HPLC

A solid-phase extraction (SPE) coupled with dispersive liquid–liquid microextraction based on the solidification of floating organic drop (DLLME-SFO) method has been developed for extraction and determination of organic bisphenol A (BPA) in different real samples. Bisphenol A was determined by high-performance liquid chromatography-fluorescence detector (HPLC-FL). Variables affecting the performance of both steps were thoroughly investigated. The analytical characteristics of the method were determined. The calibration graph is linear in the range of 0.005–10 ng g −1 with detection limit of 0.002 ng g −1 . The relative standard deviation (RSD) for of BPA in different samples are in the range of 6.8–9.6 % ( n = 5). The obtained results show that SPE-DLLME-SFO combined with HPLC-FL is a fast and simple method for the determination of BPA in food and environmental samples.