Dopamine D1 Receptor Gene Expression Studies in Unilateral 6-Hydroxydopamine-Lesioned Parkinson’s Rat: Effect of 5-HT, GABA, and Bone Marrow Cell Supplementation

Parkinson’s disease is the second most common neurodegenerative disorder and remains incurable. Many potential compensatory mechanisms have now been proposed; these are both dopaminergic, focused on enhancing effects or exposure to existing dopamine, and non-dopaminergic, being focused on reducing activity of the indirect striatal output pathway. In the present study, the effects of serotonin, gamma-aminobutyric acid, and bone marrow cell supplementation intranigrally to the substantia nigra on unilateral 6-hydroxydopamine-infused rats were analyzed individually. Dopaminergic binding parameters were done by Scatchard analysis of dopamine D 1 receptor-binding assay using [ 3 H]SCH 23390. In the corpus striatum, 6-hydroxydopamine-infused rats showed a significant decrease in B max ( P