Palladium-catalyzed C(sp3)-C(sp2) coupling: synthesis of C(3)-arylphthalides

Palladium-catalyzed C(sp3)-C(sp2) coupling: synthesis of C(3)-arylphthalides

We have achieved an efficient synthesis of C(3)-arylphthalides by coupling C(3)-bromophthalides and arylboronic acids under palladium catalysis. The C(sp 3 )-C(sp 2 ) coupling worked well in the presence of water to provide products in a high yield. Graphical Abstract

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Veröffentlicht in:Chemical papers 2024-07, Vol.78 (10), p.5985-5991
Hauptverfasser: Rao, H. Surya Prakash, Prabhakaran, J.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biotechnology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Industrial Chemistry/Chemical Engineering
Materials Science
Medicinal Chemistry
Original Paper
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Zusammenfassung:We have achieved an efficient synthesis of C(3)-arylphthalides by coupling C(3)-bromophthalides and arylboronic acids under palladium catalysis. The C(sp 3 )-C(sp 2 ) coupling worked well in the presence of water to provide products in a high yield. Graphical Abstract
ISSN:0366-6352
1336-9075
2585-7290
DOI:10.1007/s11696-024-03520-4