NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia

NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia

Objective To investigate the relationship between NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to analyze NQO1 C...

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Veröffentlicht in:Chinese journal of cancer research 2012-12, Vol.24 (4), p.317-322
Hauptverfasser: Su, Xiu-Lan, Yan, Mei-Rong, Yang, Ling, Qimuge-Suyila
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Medicine & Public Health
Original Article
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Zusammenfassung:Objective To investigate the relationship between NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results Among the colon cancer patients, the incidence of NQO1 T allele (53.29%) was significantly higher than it in control group (33.75%, P
ISSN:1000-9604
1993-0631
DOI:10.1007/s11670-012-0270-0