simple and selective detection method for aristolochic acid in crude drugs using solid-phase extraction

The official Japanese method for analyzing aristolochic acid I (AA-I) in Asiasarum root using conventional high-performance liquid chromatography (HPLC) is described in the Japanese Pharmacopoeia, Sixteenth Edition. Interfering peaks of AA-I sometimes appear after HPLC analysis of crude drugs. A sel...

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Veröffentlicht in:	Journal of natural medicines 2013-10, Vol.67 (4), p.838-843
Hauptverfasser:	Tagami, Takaomi, Takeda, Akihiro, Asada, Akiko, Aoyama, Airin, Doi, Takahiro, Kawaguchi, Masami, Kajimura, Keiji, Sawabe, Yoshiyuki, Obana, Hirotaka, Yamasaki, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aristolochic Acids - analysis Biomedical and Life Sciences Biomedicine Chromatography, High Pressure Liquid Chromatography, Liquid Complementary & Alternative Medicine drugs Drugs, Chinese Herbal - chemistry high performance liquid chromatography Mass Spectrometry Medicinal Chemistry Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Sciences quality control Solid Phase Extraction Zingiber officinale - chemistry
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Zusammenfassung:	The official Japanese method for analyzing aristolochic acid I (AA-I) in Asiasarum root using conventional high-performance liquid chromatography (HPLC) is described in the Japanese Pharmacopoeia, Sixteenth Edition. Interfering peaks of AA-I sometimes appear after HPLC analysis of crude drugs. A selective analytical method is needed to determine definitively whether AA-I is present in crude drugs. In this study, we developed a selective method that combined solid-phase extraction and liquid chromatography/mass spectrometry (LC/MS) which may be useful for identifying AA-I in crude drugs and for quality control.
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-012-0739-7