Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents

We describe the antinociceptive and anti-inflammatory properties of citronellol (CT) in rodents. CT, a monoterpene alcohol, is a naturally occurring monoterpene compound prevalent in essential oils of various aromatic plant species, such as Cymbopogon citratus. In mice, when evaluated against acetic...

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Veröffentlicht in:	Journal of natural medicines 2012-10, Vol.66 (4), p.637-644
Hauptverfasser:	Brito, Renan G, Guimarães, Adriana G, Quintans, Jullyana S. S, Santos, Marcio R. V, De Sousa, Damião P, Badaue-Passos, Daniel, Jr, de Lucca, Waldecy, Jr, Brito, Fabíola A, Barreto, Emiliano O, Oliveira, Aldeídia P, Quintans, Lucindo J., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - toxicity alcohols analgesics Analgesics - therapeutic use Animals anti-inflammatory activity Anti-Inflammatory Agents - therapeutic use antioxidant activity Biomedical and Life Sciences Biomedicine Carrageenan - toxicity citronellol Complementary & Alternative Medicine Cymbopogon citratus essential oils formalin in vitro studies Lipopolysaccharides - toxicity macrophages Macrophages - drug effects Macrophages - metabolism Male Medicinal Chemistry Mice Monoterpenes - therapeutic use nitric oxide Nitric Oxide - metabolism Nociception - drug effects Original Paper pain Pharmacology/Toxicology Pharmacy Plant Sciences Pleurisy - chemically induced Pleurisy - drug therapy tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	We describe the antinociceptive and anti-inflammatory properties of citronellol (CT) in rodents. CT, a monoterpene alcohol, is a naturally occurring monoterpene compound prevalent in essential oils of various aromatic plant species, such as Cymbopogon citratus. In mice, when evaluated against acetic-acid-induced abdominal writhing, CT (25, 50 and 100 mg/kg, i.p.) reduced (P
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-012-0632-4