Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid...

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Veröffentlicht in:Journal of natural medicines 2009-10, Vol.63 (4), p.437-442
Hauptverfasser: Vaidya, Hitesh, Rajani, Mandapati, Sudarsanam, Vasudevan, Padh, Harish, Goyal, Ramesh
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Sprache:eng
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Zusammenfassung:We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly ( P  
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-009-0350-8