Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete

Different parts of 65 plant species from the Greek island of Crete have been extracted and the 249 extracts obtained have been investigated for in-vitro antiprotozoal activity. Their activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum and Leishmania donova...

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Veröffentlicht in:	Journal of natural medicines 2007-01, Vol.61 (1), p.38-45
Hauptverfasser:	Fokialakis, N, Kalpoutzakis, E, Tekwani, B.L, Khan, S.I, Kobaisy, M, Skaltsounis, A.L, Duke, S.O
Format:	Artikel
Sprache:	eng
Schlagworte:	antileishmanial activity antimalarial activity antimalarials antimicrobial properties antiprotozoal agents in vitro studies Leishmania donovani medicinal plants plant extracts Plasmodium falciparum
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Zusammenfassung:	Different parts of 65 plant species from the Greek island of Crete have been extracted and the 249 extracts obtained have been investigated for in-vitro antiprotozoal activity. Their activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum and Leishmania donovani promastigotes was determined. Their cytotoxicity on a mammalian kidney fibroblast (Vero) cell line was also tested. Dichloromethane and methanol extracts of Berberis cretica and methanol extracts of Cytinus hypocistis subsp. hypocistis, C. hypocistis subsp. orientalis, and C. ruber had significant activity against both strains of P. falciparum (IC50
ISSN:	1861-0293 1340-3443 1861-0293
DOI:	10.1007/s11418-006-0013-y