Stereoselective Synthesis of Alicylic Amines

Stereoselective Synthesis of Alicylic Amines

The hydrogenation 4-alkylanilines over Rh/silica catalysts display an antipathetic particle size effect suggesting that the active site is a terrace face. The effect of the solvent on product cis : trans ratio was related to polar solvents stabilising an imine intermediate. The products inhibited th...

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Veröffentlicht in:Topics in catalysis 2010-09, Vol.53 (15-18), p.1121-1125
Hauptverfasser: Graham, Kristoffer F., Hindle, Kenneth T., David Jackson, S., Williams, David J. M., Wuttke, Stefan
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Industrial Chemistry/Chemical Engineering
Original Paper
Pharmacy
Physical Chemistry
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Zusammenfassung:The hydrogenation 4-alkylanilines over Rh/silica catalysts display an antipathetic particle size effect suggesting that the active site is a terrace face. The effect of the solvent on product cis : trans ratio was related to polar solvents stabilising an imine intermediate. The products inhibited the reaction due to their increased basicity which allowed a strong metal–nitrogen interaction.
ISSN:1022-5528
1572-9028
DOI:10.1007/s11244-010-9544-2