A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes

A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes

A new approach to the synthesis of organic ligands of asialoglycoprotein receptor was suggested. It was shown that the azido-containing tervalent N -acetylglucosamine and N -acetyl-mannosamine derivatives obtained by this method can serve as convenient starting compounds for the synthesis of therape...

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Veröffentlicht in:Russian chemical bulletin 2015-07, Vol.64 (7), p.1655-1662
Hauptverfasser: Maklakova, S. Yu, Kucherov, F. A., Petrov, R. A., Gopko, V. V., Shipulin, G. A., Zatsepin, T. S., Beloglazkina, E. K., Zyk, N. V., Majouga, A. G., Koteliansky, V. E.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:A new approach to the synthesis of organic ligands of asialoglycoprotein receptor was suggested. It was shown that the azido-containing tervalent N -acetylglucosamine and N -acetyl-mannosamine derivatives obtained by this method can serve as convenient starting compounds for the synthesis of therapeutical conjugates with oligonucleotides containing a terminal alkyne.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-015-1056-6