The use of mixtures of ligands in the Ir-catalyzed asymmetric reductive amination of 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

A comparative testing of complex catalysts with homo and hetero combinations of chiral and achiral monodentate phosphite- and phosphine-type ligands in the Ir-catalyzed asymmetric direct reductive amination of 2,3,4,9-tetrahydro-1 H -сarbozol-1-ones was carried out. A positive effect of the use in t...

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Veröffentlicht in:Russian chemical bulletin 2015-07, Vol.64 (7), p.1591-1594
Hauptverfasser: Lyubimov, S. E., Ozolin, D. V., Pavlov, A. A., Ivanov, P. Yu, Mayorov, K. B., Velezheva, V. S., Davankov, V. A., Nikonenko, B. V.
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Sprache:eng
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Zusammenfassung:A comparative testing of complex catalysts with homo and hetero combinations of chiral and achiral monodentate phosphite- and phosphine-type ligands in the Ir-catalyzed asymmetric direct reductive amination of 2,3,4,9-tetrahydro-1 H -сarbozol-1-ones was carried out. A positive effect of the use in the reaction of a mixture of chiral and achiral ligands was demonstrated. This approach makes feasible a one-pot synthesis of valuable biologically active compounds of (tetrahydro-1 H -carbazol-1-yl)amine series.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-015-1046-8