Inhibition of the procoagulant activity of blood platelets by vinylsulfonyl derivatives of pyrrolidine-2-carboxylic acid

Novel derivatives of 4-(vinylsulfonyl)pyrrolidine-2-carboxylic acids inhibit the exposure of phosphatidylserine by platelets upon activation with thrombin. The heterocyclic inhibitors were synthesized by 1,3-dipolar cycloaddition of divinyl sulfone to azomethine ylides followed by functionalization...

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Veröffentlicht in:	Russian chemical bulletin 2011-04, Vol.60 (4), p.679-684
Hauptverfasser:	Kudryavtsev, K. V., Podoplelova, N. A., Novikova, A. A., Panteleev, M. A., Zabolotnev, D. V., Zefirov, N. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Inorganic Chemistry Organic Chemistry
Online-Zugang:	Volltext
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Zusammenfassung:	Novel derivatives of 4-(vinylsulfonyl)pyrrolidine-2-carboxylic acids inhibit the exposure of phosphatidylserine by platelets upon activation with thrombin. The heterocyclic inhibitors were synthesized by 1,3-dipolar cycloaddition of divinyl sulfone to azomethine ylides followed by functionalization of the endocyclic nitrogen atom.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-011-0106-y