A new meroterpenoid from the marine fungus Aspergillus versicolor (Vuill.) Tirab

A new meroterpenoid from the marine fungus Aspergillus versicolor (Vuill.) Tirab

A new meroterpenoid asperdemin ( 1 ) and two known compounds, viz. , diorcinol ( 2 ) and viridicatol ( 3 ), were isolated from the marine fungus Aspergillus versicolor . The structures of these compounds were established by NMR spectroscopy and high-resolution mass spectrome-try. The absolute stereo...

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Veröffentlicht in:Russian chemical bulletin 2010-04, Vol.59 (4), p.852-856
Hauptverfasser: Yurchenko, A. N., Smetanina, O. F., Kalinovsky, A. I., Pivkin, M. V., Dmitrenok, P. S., Kuznetsova, T. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:A new meroterpenoid asperdemin ( 1 ) and two known compounds, viz. , diorcinol ( 2 ) and viridicatol ( 3 ), were isolated from the marine fungus Aspergillus versicolor . The structures of these compounds were established by NMR spectroscopy and high-resolution mass spectrome-try. The absolute stereochemistry of 1 was determined by modified Mosher’s method. The antimicrobial activity of the total extract from A. versicolor was attributed to diorcinol ( 2 ). Asperdemin exhibits weak cytostatic and membranolytic activities in developing embryos of the sea urchin Strongylocentrotus nudus .
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-010-0173-5