N-substituted tetrahydro-1,3-oxazines and -oxazolidines. 2. Nitration of N-(ω-acylamino-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and -oxazolidines

N-substituted tetrahydro-1,3-oxazines and -oxazolidines. 2. Nitration of N-(ω-acylamino-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and -oxazolidines

Nitration of N -(ω-acylamino0-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and N -(ω-acylamino-β,β-dinitroalkyl)oxazolidines resulted in O-nitrates bearing amide, dinitromethylene, and nitroamine groups. It was found that nitration can be accompanied by N-hydroxymethylation of the amide group. Three nit...

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Veröffentlicht in:Russian chemical bulletin 2009-10, Vol.58 (10), p.2103-2108
Hauptverfasser: Korepin, A. G., Galkin, P. V., Perepelkina, E. K., Glushakova, N. M., Eremenko, I. L., Eremenko, L. T.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:Nitration of N -(ω-acylamino0-β,β-dinitroalkyl)tetrahydro-1,3-oxazines and N -(ω-acylamino-β,β-dinitroalkyl)oxazolidines resulted in O-nitrates bearing amide, dinitromethylene, and nitroamine groups. It was found that nitration can be accompanied by N-hydroxymethylation of the amide group. Three nitrates synthesized were tested for, and exhibited good level of, cardioprotection.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-009-0287-9