1,3,5-Triazinenitrolic acids. Synthesis and NO-releasing properties

Reactions of salts of 1,3,5-triazine dinitromethyl derivatives with nitrogen dioxide that result mainly in 1,3,5-triazinenitrolic acids are investigated. The behavior of nitrolic acid in electroreduction at a mercury drop electrode at various pH was studied; oxygen was shown to accelerate the proces...

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Veröffentlicht in:	Russian chemical bulletin 2009-09, Vol.58 (9), p.1962-1972
Hauptverfasser:	Bakharev, V. V., Gidaspov, A. A., Peresedova, E. V., Granik, V. G., Grigor’ev, N. B., Levina, V. I., Severina, I. S., Shchegolev, A. Yu, Dmitriev, D. E., Sheremetev, A. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Inorganic Chemistry Organic Chemistry
Online-Zugang:	Volltext
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Zusammenfassung:	Reactions of salts of 1,3,5-triazine dinitromethyl derivatives with nitrogen dioxide that result mainly in 1,3,5-triazinenitrolic acids are investigated. The behavior of nitrolic acid in electroreduction at a mercury drop electrode at various pH was studied; oxygen was shown to accelerate the process. The promoting effect of nitrolic acids on the activity of soluble guanylate cyclase of human platelets was shown. The studied nitrolic acids are active donors of nitric oxide, a universal and important regulator of cell metabolism functions. NO-releasing properties of furoxans are investigated.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-009-0268-z