A new approach to the synthesis of pyrido[4,3-b]indole derivatives (γ-carbolines) via cyclization of enamino dinitriles

A new approach to the synthesis of pyrido[4,3-b]indole derivatives (γ-carbolines) via cyclization of enamino dinitriles

Reactions of 2-dicyanomethylidene-3-ethoxymethylidene-2,3-dihydroindole with various amines afforded enamino dinitriles and the corresponding pyrido[4,3- b ]indoles (γ-carbolines). 3-Amino-4-cyano-5 H -pyrido[4,3- b ]indole reacted with cyclohexanone to give pentacyclic 13-amino-2,3,4,12-tetrahydro-...

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Veröffentlicht in:Russian chemical bulletin 2008-11, Vol.57 (11), p.2410-2417
Hauptverfasser: Smirnova, O. B., Golovko, T. V., Alekseeva, L. M., Shashkov, A. S., Granik, V. G.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:Reactions of 2-dicyanomethylidene-3-ethoxymethylidene-2,3-dihydroindole with various amines afforded enamino dinitriles and the corresponding pyrido[4,3- b ]indoles (γ-carbolines). 3-Amino-4-cyano-5 H -pyrido[4,3- b ]indole reacted with cyclohexanone to give pentacyclic 13-amino-2,3,4,12-tetrahydro-1 H -benzo[ b ]indolo[2,3- f ]-1,8-naphthyridine. Alkylation of pyrido[4,3- b ]indoles with various alkylating agents was studied.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-008-0344-9