One-pot rapid synthesis of thiazole-substituted pyrazolyl-4-thiazolidinones mediated by diisopropylethylammonium acetate

One-pot rapid synthesis of thiazole-substituted pyrazolyl-4-thiazolidinones mediated by diisopropylethylammonium acetate

A convenient one-pot, rapid and scalable synthetic protocol has been developed for recently reported anti-inflammatory agents, thiazole-substituted pyrazolyl-4-thiazolidinones. Quantitative multicomponent cyclocondensation of 3-(4-methyl-2-substituted thiazol-5-yl)-1-phenyl-1 H -pyrazole-4-carbaldeh...

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Veröffentlicht in:Research on chemical intermediates 2015-11, Vol.41 (11), p.8955-8964
Hauptverfasser: Khillare, Lalit D., Bhosle, Manisha R., Deshmukh, Amarsinh R., Mane, Ramrao A.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
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Beschreibung
Zusammenfassung:A convenient one-pot, rapid and scalable synthetic protocol has been developed for recently reported anti-inflammatory agents, thiazole-substituted pyrazolyl-4-thiazolidinones. Quantitative multicomponent cyclocondensation of 3-(4-methyl-2-substituted thiazol-5-yl)-1-phenyl-1 H -pyrazole-4-carbaldehydes ( 5a , b ), amines and mercaptoacetic acid has been carried out in safer medium, diisopropylethylammonium acetate, at room temperature. The optimisation details of the developed novel protocol are recorded.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-015-1940-6