Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by Fe3O4 nanoparticles

Highly effective one-pot synthesis of benzo[ b ][1,5]diazepines has been achieved by three-component (or, in situ, including catalyst and solvent, five-component) reaction of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by magnetite (Fe 3 O 4 ) nanoparticles. Pharmaceutically and biologically active heterocyclic compounds including benzodiazepine derivatives were efficiently synthesized in excellent yields and short reaction times at room temperature. The significant features of the Fe 3 O 4 nanoparticles are: easy preparation, cost-effectiveness, high stability, easy separation, low loading, and reusability of the catalyst. The heterogeneous nanoparticles were fully characterized by XRD, EDX, BET, SEM, TEM, and FT-IR analysis.