Al-HMS-20 catalyzed synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines via three-component reaction

A large library of pyrano[2,3- d ]pyrimidines and pyrido[2,3- d ]pyrimidines was synthesized through the reaction between various aromatic aldehydes, malononitrile and pyrimidine derivatives in the presence of Al-HMS-20 as the catalyst in EtOH at room temperature after 12 h. This multi-component approach is a very efficient and economical benign process.