Creation of Modified Forms of Amiodarone with Glycyrrhizic Acid and Its Monoammonium Salt and Study of Their Cytotoxicity on Hela Cells

The aim of this work is to create new modified dosage forms of amiodarone with triterpene glycosides in various stoichiometric ratios and to study their cytotoxicity on HeLa cells. Complexes of glycyrrhizic acid (GA) and the monoammonium salt of glycyrrhizic acid (MASGA) with amiodarone hydrochloride were obtained, characterized by certain physicochemical parameters, and studied by IR and UV spectroscopy. The supramolecular complexes were formed mainly through weak intermolecular interactions such as hydrogen bonding and ion-dipole, electrostatic, and dipole-dipole interactions. The quantitative content of GA and MASGA in the complexes was shown to affect the cytotoxicity of the drug. A modified form of amiodarone may be developed in future research and could become a promising antiarrhythmic drug.