Use of Surfactants in Quality Control of Solid Dosage Forms with Respect to Microbiological Indicators

The present study focuses on the use of surfactants (SA) in quality control of solid dosage forms. Features of the dissolution of solid dosage forms and factors affecting the extraction of microorganisms from drug samples are discussed. The properties of SA required to neutralize the antimicrobial activity of drugs are considered. Experimental data on the extraction of microorganisms from and the neutralization of antimicrobial action of solid dosage forms of non-sterile drugs are presented.