Preclinical study of the α₂-adrenostimulant Brimozolin (brimonidine)

A preclinical study of the α₂ -adrenostimulant Brimozolin (brimonidine tartrate), synthesized by an original method at OAO Center for the Chemistry of Therapeutic Agents_All-Russian Chemico-Pharmaceutical Research Institute (TsKhLS-VNIKhFI), was performed using 29 rabbits. Brimozolin eye drops decre...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2009-07, Vol.43 (7), p.375-377, Article 375
Hauptverfasser:	Ermakova, V. N, Zakharova, G. P, Rybko, G. V
Format:	Artikel
Sprache:	eng
Schlagworte:	chronic toxicity histological studies hydrodynamic parameters intraocular pressure Medicine Molecular-Biological Problems of Drug Design and Mechanisms of Drug Action Organic Chemistry Pharmacology/Toxicology Pharmacy Specific activity
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Zusammenfassung:	A preclinical study of the α₂ -adrenostimulant Brimozolin (brimonidine tartrate), synthesized by an original method at OAO Center for the Chemistry of Therapeutic Agents_All-Russian Chemico-Pharmaceutical Research Institute (TsKhLS-VNIKhFI), was performed using 29 rabbits. Brimozolin eye drops decreased intraocular pressure in the intact eyes of experimental animals by 3 - 5 mmHg for one day by producing significant increases in the outflow of aqueous humor and suppressing its production. Histological studies of the outer and inner layers of the eye showed that there were no changes. This agent is recommended for clinical trials.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-009-0320-1