New method for the synthesis of methyl-4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-1-piperazinecarboxylate

New method for the synthesis of methyl-4-[(3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-1-piperazinecarboxylate

A new simple method involving a reduced number of steps is proposed for the synthesis of methyl-4-[(3, 4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-4-piperazinecarboxylate (GR-89696), which is an agonist of κ-opioid receptors (Kd = 0.41 nM).

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2009-02, Vol.43 (2), p.115-117
Hauptverfasser: Kasatkin, I. K, Nazarov, G. V, Galan, S. E, Babkin, I. Yu, Mitrofanov, D. A, Goncharov, V. M, Scherbakov, D. A, Stepnov, V. A
Format: Artikel
Sprache:eng
Schlagworte:
Drug Synthesis Methods and Manufacturing Technology
GR-89696
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
piperazine
κ-agonist
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Beschreibung
Zusammenfassung:A new simple method involving a reduced number of steps is proposed for the synthesis of methyl-4-[(3, 4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-4-piperazinecarboxylate (GR-89696), which is an agonist of κ-opioid receptors (Kd = 0.41 nM).
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0243-x