Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives

Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives

Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3 , 4, 11, 15 – 17, and 20 – 22 were tested for analgesic activity. After ip administration all compounds induce...

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Veröffentlicht in:Pharmaceutical chemistry journal 2009, Vol.43 (1), p.25-29
Hauptverfasser: El-Nezhawy, A. O. H., El-Naem, S. I., Galal, S. A., El-Diwani, H. I., Abdel Salam, O. M. E., Baiomy, A. R.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
The Search for New Drugs
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Zusammenfassung:Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3 , 4, 11, 15 – 17, and 20 – 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0234-y