Synthesis and coronary vasodilating activity of 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and piperidine rings

Synthesis and coronary vasodilating activity of 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and piperidine rings

Methods for the synthesis of 6,6-substituted 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and pyridine rings have been developed on the basis of condensed 2-chloropyridine derivatives. The coronary vasodilating activity of the synthesized compounds has been studied.

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Veröffentlicht in:Pharmaceutical chemistry journal 2008-12, Vol.42 (12), p.668-669
Hauptverfasser: Dabaeva, V. V, Pilosyan, S. G, Noravyan, A. S, Bagdasaryan, M. P, Grigoryan, G. Kh, Aleksanyan, R. A
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:Methods for the synthesis of 6,6-substituted 1-aminopyrazolo[3,4-b]pyridines with fused tetrahydropyran (-thiopyran) and pyridine rings have been developed on the basis of condensed 2-chloropyridine derivatives. The coronary vasodilating activity of the synthesized compounds has been studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0218-y