Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

This study describes the preparation, biodistribution and absorbed dose prediction of 67 Ga and 99m Tc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67 Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99m Tc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67 Ga-BBN would result 2 times higher absorbed dose compare to 99m Tc-BBN.