Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Nanocapsules (NCs) of poly-ε-caprolactone (PCL NC) and poly-ε-caprolactone coated with chitosan (CS-PCL NC) loaded with technetium-99m methoxyisobutylisonitrile ( 99m Tc-MIBI) were employed as a model to understand the role of these nanocarriers in the veterinary area. 99m Tc-MIBI-NCs and 99m Tc-MIBI were administrated by intramammary via in rats. The level of radioactivity in the blood was lower when NCs were employed in all times investigated. The results obtained suggest that NCs could be an alternative method for treatment of intramammary diseases in animals, once the data showed high retention in this tissue, increasing the drug residence time on the target.