The Crystal Structure and Cytotoxicity of Centrosymmetric Copper(II) Complex Derived from S-methyldithiocarbazate with Isatin

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human non-metastatic mammary gland adenocarcinoma cell line with an IC 50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) 2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. Graphical Abstract Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 and MDA-MB-231 breast cancer cell lines. The compound was found to be selectively active against MCF-7 cell line with an IC 50 value 0.45 μg/mL.