Inclusion of chemotherapeutic agents in substituted β-cyclodextrin derivatives

The stabilities of the inclusion compounds of three chemotherapeutic agents, camptothecin (CPT), docetaxel (DOC) and idarubicin (IDA), plus a model compound 1,4-dihydroxyanthraquinone (DHA) with several β-cyclodextrin (β-CD) derivatives were investigated by solubility measurements, isothermal titrat...

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Veröffentlicht in:	Journal of Inclusion Phenomena and Macrocyclic Chemistry 2011-04, Vol.69 (3-4), p.303-307
Hauptverfasser:	Thiele, Carolin, Auerbach, Dagmar, Jung, Gregor, Wenz, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Crystallography and Scattering Methods Food Science Organic Chemistry Original Article
Online-Zugang:	Volltext
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Zusammenfassung:	The stabilities of the inclusion compounds of three chemotherapeutic agents, camptothecin (CPT), docetaxel (DOC) and idarubicin (IDA), plus a model compound 1,4-dihydroxyanthraquinone (DHA) with several β-cyclodextrin (β-CD) derivatives were investigated by solubility measurements, isothermal titration microcalorimetry and fluorescence anisotropy measurements. Ionic heptakis-(6-deoxy-6-thioethers) of β-CD were found to exhibit very high binding potentials for these drugs making them to good candidates for advanced drug delivery.
ISSN:	0923-0750 1573-1111
DOI:	10.1007/s10847-010-9741-4